ZNF266-MATK Fusion FISH Probe
The ZNF266-MATK Fusion FISH Probe is used to confirm a fusion of the ZNF266 and MATK genes. The fusion of the ZNF266 and MATK genes has been associated with Uveal Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZNF266-MATK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-RERE | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-REOR | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-REGO | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-REGR | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-REAQ | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-ORRE | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-OROR | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-ORGO | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-GORE | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-GOOR | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-GOGO | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-GOGR | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-GRRE | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-GROR | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-GRGO | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-GRGR | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-AQRE | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-AQOR | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-AQGO | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-AQGR | 20 (40 μL) | 200 μL |
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| ZNF266-MATK-20-AQAQ | 20 (40 μL) | 200 μL |
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MATK Gene Summary
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Megakaryocyte-associated Tyrosine Kinase
Chromosome: CHR19: 3777966 -3801810
Locus: 19p13.3
ZNF266 Gene Summary
This gene encodes a protein containing many tandem zinc-finger motifs. Zinc fingers are protein or nucleic acid-binding domains, and may be involved in a variety of functions, including regulation of transcription. This gene is located in a cluster of similar genes encoding zinc finger proteins on chromosome 19. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Sep 2012]
Gene Name: Zinc Finger Protein 266
Chromosome: CHR19: 9523270 -9546234
Locus: 19p13.2
Gene Diseases
The ZNF266 MATK Fusion has been associated with the following diseases:
| Disease Name |
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| Uveal Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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