ZNF189-BAAT Fusion FISH Probe
The ZNF189-BAAT Fusion FISH Probe is used to confirm a fusion of the ZNF189 and BAAT genes. The fusion of the ZNF189 and BAAT genes has been associated with Lung Squamous Cell Carcinoma, and Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZNF189-BAAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-RERE | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-REOR | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-REGO | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-REGR | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-REAQ | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-ORRE | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-OROR | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-ORGO | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-GORE | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-GOOR | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-GOGO | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-GOGR | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-GRRE | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-GROR | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-GRGO | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-GRGR | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-AQRE | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-AQOR | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-AQGO | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-AQGR | 20 (40 μL) | 200 μL |
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| ZNF189-BAAT-20-AQAQ | 20 (40 μL) | 200 μL |
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BAAT Gene Summary
The protein encoded by this gene is a liver enzyme that catalyzes the transfer of C24 bile acids from the acyl-CoA thioester to either glycine or taurine, the second step in the formation of bile acid-amino acid conjugates. The bile acid conjugates then act as a detergent in the gastrointestinal tract, which enhances lipid and fat-soluble vitamin absorption. Defects in this gene are a cause of familial hypercholanemia (FHCA). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Bile Acid-CoA:amino Acid N-acyltransferase
Chromosome: CHR9: 104122698 -104147287
Locus: 9q31.1
ZNF189 Gene Summary
Kruppel-like zinc finger proteins such as ZNF189 contain a conserved stretch of 7 amino acids that connects a variable number of DNA-binding zinc finger repeats of the cys(2)his(2) (C2H2) type (summarized by Odeberg et al., 1998 [PubMed 9653648]). Approximately 30% of human Kruppel-like zinc finger proteins contain an N-terminal Kruppel-associated box (KRAB) domain. The KRAB domain consists of approximately 75 amino acids that may be subdivided into an A box, which is present in every KRAB domain and is essential for transcriptional repression, and a B box, which is not always present.[supplied by OMIM, May 2010]
Gene Name: Zinc Finger Protein 189
Chromosome: CHR9: 104161162 -104172942
Locus: 9q31.1
Gene Diseases
The ZNF189 BAAT Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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