ZNF148-MYLK Fusion FISH Probe
The ZNF148-MYLK Fusion FISH Probe is used to confirm a fusion of the ZNF148 and MYLK genes. The fusion of the ZNF148 and MYLK genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZNF148-MYLK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-RERE | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-REOR | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-REGO | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-REGR | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-REAQ | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-ORRE | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-OROR | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-ORGO | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-GORE | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-GOOR | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-GOGO | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-GOGR | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-GRRE | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-GROR | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-GRGO | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-GRGR | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-AQRE | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-AQOR | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-AQGO | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-AQGR | 20 (40 μL) | 200 μL |
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| ZNF148-MYLK-20-AQAQ | 20 (40 μL) | 200 μL |
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MYLK Gene Summary
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008]
Gene Name: Myosin Light Chain Kinase
Chromosome: CHR3: 123331142 -123603149
Locus: 3q21.1
ZNF148 Gene Summary
The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. [provided by RefSeq, Feb 2017]
Gene Name: Zinc Finger Protein 148
Chromosome: CHR3: 124944512 -125094198
Locus: 3q21.2
Gene Diseases
The ZNF148 MYLK Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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