ZMYND8-TFE3 Fusion FISH Probe
The ZMYND8-TFE3 Fusion FISH Probe is used to confirm a fusion of the ZMYND8 and TFE3 genes. The fusion of the ZMYND8 and TFE3 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZMYND8-TFE3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-RERE | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-REOR | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-REGO | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-REGR | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-REAQ | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-ORRE | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-OROR | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-ORGO | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-GORE | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-GOOR | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-GOGO | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-GOGR | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-GRRE | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-GROR | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-GRGO | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-GRGR | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-AQRE | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-AQOR | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-AQGO | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-AQGR | 20 (40 μL) | 200 μL |
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| ZMYND8-TFE3-20-AQAQ | 20 (40 μL) | 200 μL |
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TFE3 Gene Summary
This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Gene Name: Transcription Factor Binding To IGHM Enhancer 3
Chromosome: CHRX: 48886241 -48900990
Locus: Xp11.23
ZMYND8 Gene Summary
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Zinc Finger MYND-type Containing 8
Chromosome: CHR20: 45838380 -45985474
Locus: 20q13.12
Gene Diseases
The ZMYND8 TFE3 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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