ZMYND8-SULF2 Fusion FISH Probe
The ZMYND8-SULF2 Fusion FISH Probe is used to confirm a fusion of the ZMYND8 and SULF2 genes. The fusion of the ZMYND8 and SULF2 genes has been associated with Ovarian Serous Cystadenocarcinoma, and Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZMYND8-SULF2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-RERE | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-REOR | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-REGO | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-REGR | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-REAQ | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-ORRE | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-OROR | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-ORGO | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-GORE | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-GOOR | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-GOGO | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-GOGR | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-GRRE | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-GROR | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-GRGO | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-GRGR | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-AQRE | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-AQOR | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-AQGO | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-AQGR | 20 (40 μL) | 200 μL |
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| ZMYND8-SULF2-20-AQAQ | 20 (40 μL) | 200 μL |
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ZMYND8 Gene Summary
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Zinc Finger MYND-type Containing 8
Chromosome: CHR20: 45838380 -45985474
Locus: 20q13.12
SULF2 Gene Summary
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).[supplied by OMIM, Mar 2008]
Gene Name: Sulfatase 2
Chromosome: CHR20: 46286149 -46415360
Locus: 20q13.12
Gene Diseases
The ZMYND8 SULF2 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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