ZMYND8-RNF43 Fusion FISH Probe
The ZMYND8-RNF43 Fusion FISH Probe is used to confirm a fusion of the ZMYND8 and RNF43 genes. The fusion of the ZMYND8 and RNF43 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZMYND8-RNF43-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-RERE | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-REOR | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-REGO | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-REGR | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-REAQ | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-ORRE | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-OROR | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-ORGO | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-GORE | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-GOOR | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-GOGO | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-GOGR | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-GRRE | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-GROR | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-GRGO | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-GRGR | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-AQRE | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-AQOR | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-AQGO | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-AQGR | 20 (40 μL) | 200 μL |
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| ZMYND8-RNF43-20-AQAQ | 20 (40 μL) | 200 μL |
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ZMYND8 Gene Summary
The protein encoded by this gene is a receptor for activated C-kinase (RACK) protein. The encoded protein has been shown to bind in vitro to activated protein kinase C beta I. In addition, this protein is a cutaneous T-cell lymphoma-associated antigen. Finally, the protein contains a bromodomain and two zinc fingers, and is thought to be a transcriptional regulator. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Zinc Finger MYND-type Containing 8
Chromosome: CHR20: 45838380 -45985474
Locus: 20q13.12
RNF43 Gene Summary
The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Gene Name: Ring Finger Protein 43
Chromosome: CHR17: 56431037 -56494931
Locus: 17q22
Gene Diseases
The ZMYND8 RNF43 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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