ZMYND11-SORBS2 Fusion FISH Probe
The ZMYND11-SORBS2 Fusion FISH Probe is used to confirm a fusion of the ZMYND11 and SORBS2 genes. The fusion of the ZMYND11 and SORBS2 genes has been associated with Brain Lower Grade Glioma, and Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZMYND11-SORBS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-RERE | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-REOR | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-REGO | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-REGR | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-REAQ | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-ORRE | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-OROR | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-ORGO | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-GORE | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-GOOR | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-GOGO | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-GOGR | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-GRRE | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-GROR | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-GRGO | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-GRGR | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-AQRE | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-AQOR | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-AQGO | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-AQGR | 20 (40 μL) | 200 μL |
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| ZMYND11-SORBS2-20-AQAQ | 20 (40 μL) | 200 μL |
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SORBS2 Gene Summary
Arg and c-Abl represent the mammalian members of the Abelson family of non-receptor protein-tyrosine kinases. They interact with the Arg/Abl binding proteins via the SH3 domains present in the carboxy end of the latter group of proteins. This gene encodes the sorbin and SH3 domain containing 2 protein. It has three C-terminal SH3 domains and an N-terminal sorbin homology (SoHo) domain that interacts with lipid raft proteins. The subcellular localization of this protein in epithelial and cardiac muscle cells suggests that it functions as an adapter protein to assemble signaling complexes in stress fibers, and that it is a potential link between Abl family kinases and the actin cytoskeleton. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Sorbin And SH3 Domain Containing 2
Chromosome: CHR4: 186506597 -186877870
Locus: 4q35.1
ZMYND11 Gene Summary
The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Name: Zinc Finger MYND-type Containing 11
Chromosome: CHR10: 180404 -300577
Locus: 10p15.3
Gene Diseases
The ZMYND11 SORBS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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