ZMIZ1-XYLT2 Fusion FISH Probe
The ZMIZ1-XYLT2 Fusion FISH Probe is used to confirm a fusion of the ZMIZ1 and XYLT2 genes. The fusion of the ZMIZ1 and XYLT2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZMIZ1-XYLT2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-RERE | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-REOR | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-REGO | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-REGR | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-REAQ | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-ORRE | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-OROR | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-ORGO | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-GORE | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-GOOR | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-GOGO | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-GOGR | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-GRRE | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-GROR | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-GRGO | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-GRGR | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-AQRE | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-AQOR | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-AQGO | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-AQGR | 20 (40 μL) | 200 μL |
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| ZMIZ1-XYLT2-20-AQAQ | 20 (40 μL) | 200 μL |
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ZMIZ1 Gene Summary
This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. The encoded protein may also play a role in sumoylation. A translocation between this locus on chromosome 10 and the protein tyrosine kinase ABL1 locus on chromosome 9 has been associated with acute lymphoblastic leukemia. [provided by RefSeq, Mar 2010]
Gene Name: Zinc Finger MIZ-type Containing 1
Chromosome: CHR10: 80828791 -81076285
Locus: 10q22.3
XYLT2 Gene Summary
The protein encoded by this gene is an isoform of xylosyltransferase, which belongs to a family of glycosyltransferases. This enzyme transfers xylose from UDP-xylose to specific serine residues of the core protein and initiates the biosynthesis of glycosaminoglycan chains in proteoglycans including chondroitin sulfate, heparan sulfate, heparin and dermatan sulfate. The enzyme activity, which is increased in scleroderma patients, is a diagnostic marker for the determination of sclerotic activity in systemic sclerosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]
Gene Name: Xylosyltransferase 2
Chromosome: CHR17: 48423392 -48438512
Locus: 17q21.33
Gene Diseases
The ZMIZ1 XYLT2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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