ZMAT3-TP63 Fusion FISH Probe
The ZMAT3-TP63 Fusion FISH Probe is used to confirm a fusion of the ZMAT3 and TP63 genes. The fusion of the ZMAT3 and TP63 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZMAT3-TP63-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-RERE | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-REOR | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-REGO | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-REGR | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-REAQ | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-ORRE | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-OROR | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-ORGO | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-GORE | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-GOOR | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-GOGO | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-GOGR | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-GRRE | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-GROR | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-GRGO | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-GRGR | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-AQRE | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-AQOR | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-AQGO | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-AQGR | 20 (40 μL) | 200 μL |
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| ZMAT3-TP63-20-AQAQ | 20 (40 μL) | 200 μL |
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TP63 Gene Summary
This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]
Gene Name: Tumor Protein P63
Chromosome: CHR3: 189349215 -189615068
Locus: 3q28
ZMAT3 Gene Summary
This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008]
Gene Name: Zinc Finger Matrin-type 3
Chromosome: CHR3: 178735010 -178789656
Locus: 3q26.32
Gene Diseases
The ZMAT3 TP63 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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