ZHX2-PPM1B Fusion FISH Probe
The ZHX2-PPM1B Fusion FISH Probe is used to confirm a fusion of the ZHX2 and PPM1B genes. The fusion of the ZHX2 and PPM1B genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZHX2-PPM1B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-RERE | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-REOR | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-REGO | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-REGR | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-REAQ | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-ORRE | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-OROR | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-ORGO | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-GORE | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-GOOR | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-GOGO | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-GOGR | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-GRRE | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-GROR | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-GRGO | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-GRGR | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-AQRE | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-AQOR | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-AQGO | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-AQGR | 20 (40 μL) | 200 μL |
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| ZHX2-PPM1B-20-AQAQ | 20 (40 μL) | 200 μL |
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PPM1B Gene Summary
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]
Gene Name: Protein Phosphatase, Mg2+/Mn2+ Dependent 1B
Chromosome: CHR2: 44395999 -44461742
Locus: 2p21
ZHX2 Gene Summary
The members of the zinc fingers and homeoboxes gene family are nuclear homodimeric transcriptional repressors that interact with the A subunit of nuclear factor-Y (NF-YA) and contain two C2H2-type zinc fingers and five homeobox DNA-binding domains. This gene encodes member 2 of this gene family. In addition to forming homodimers, this protein heterodimerizes with member 1 of the zinc fingers and homeoboxes family. [provided by RefSeq, Jul 2008]
Gene Name: Zinc Fingers And Homeoboxes 2
Chromosome: CHR8: 123793900 -123986755
Locus: 8q24.13
Gene Diseases
The ZHX2 PPM1B Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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