ZFP91-LPXN Fusion FISH Probe
The ZFP91-LPXN Fusion FISH Probe is used to confirm a fusion of the ZFP91 and LPXN genes. The fusion of the ZFP91 and LPXN genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZFP91-LPXN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-RERE | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-REOR | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-REGO | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-REGR | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-REAQ | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-ORRE | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-OROR | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-ORGO | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-GORE | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-GOOR | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-GOGO | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-GOGR | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-GRRE | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-GROR | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-GRGO | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-GRGR | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-AQRE | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-AQOR | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-AQGO | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-AQGR | 20 (40 μL) | 200 μL |
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| ZFP91-LPXN-20-AQAQ | 20 (40 μL) | 200 μL |
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LPXN Gene Summary
The product encoded by this gene is preferentially expressed in hematopoietic cells and belongs to the paxillin protein family. Similar to other members of this focal-adhesion-associated adaptor-protein family, it has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of focal adhesion kinase family. As a substrate for a tyrosine kinase in lymphoid cells, this protein may also function in, and be regulated by, tyrosine kinase activity. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]
Gene Name: Leupaxin
Chromosome: CHR11: 58294343 -58345639
Locus: 11q12.1
ZFP91 Gene Summary
The protein encoded by this gene is a member of the zinc finger family of proteins. The gene product contains C2H2-type domains, which are the classical zinc finger domains found in numerous nucleic acid-binding proteins. This protein functions as a regulator of the non-canonical NF-kappaB pathway in lymphotoxin-beta receptor signaling. Alternative splicing results in multiple transcript variants. A read-through transcript variant composed of ZFP91 and the downstream CNTF gene sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. A ZFP91-related pseudogene has also been identified on chromosome 2. [provided by RefSeq, Oct 2010]
Gene Name: ZFP91 Zinc Finger Protein
Chromosome: CHR11: 58346586 -58389023
Locus: 11q12.1
Gene Diseases
The ZFP91 LPXN Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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