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ZFHX3-WWP2 Fusion FISH Probe

The ZFHX3-WWP2 Fusion FISH Probe is used to confirm a fusion of the ZFHX3 and WWP2 genes. The fusion of the ZFHX3 and WWP2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ZFHX3-WWP2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ZFHX3-WWP2-20-RERE 20 (40 μL) 200 μL
ZFHX3-WWP2-20-REOR 20 (40 μL) 200 μL
ZFHX3-WWP2-20-REGO 20 (40 μL) 200 μL
ZFHX3-WWP2-20-REGR 20 (40 μL) 200 μL
ZFHX3-WWP2-20-REAQ 20 (40 μL) 200 μL
ZFHX3-WWP2-20-ORRE 20 (40 μL) 200 μL
ZFHX3-WWP2-20-OROR 20 (40 μL) 200 μL
ZFHX3-WWP2-20-ORGO 20 (40 μL) 200 μL
ZFHX3-WWP2-20-ORAQ 20 (40 μL) 200 μL
ZFHX3-WWP2-20-GORE 20 (40 μL) 200 μL
ZFHX3-WWP2-20-GOOR 20 (40 μL) 200 μL
ZFHX3-WWP2-20-GOGO 20 (40 μL) 200 μL
ZFHX3-WWP2-20-GOGR 20 (40 μL) 200 μL
ZFHX3-WWP2-20-GOAQ 20 (40 μL) 200 μL
ZFHX3-WWP2-20-GRRE 20 (40 μL) 200 μL
ZFHX3-WWP2-20-GROR 20 (40 μL) 200 μL
ZFHX3-WWP2-20-GRGO 20 (40 μL) 200 μL
ZFHX3-WWP2-20-GRGR 20 (40 μL) 200 μL
ZFHX3-WWP2-20-GRAQ 20 (40 μL) 200 μL
ZFHX3-WWP2-20-AQRE 20 (40 μL) 200 μL
ZFHX3-WWP2-20-AQOR 20 (40 μL) 200 μL
ZFHX3-WWP2-20-AQGO 20 (40 μL) 200 μL
ZFHX3-WWP2-20-AQGR 20 (40 μL) 200 μL
ZFHX3-WWP2-20-AQAQ 20 (40 μL) 200 μL

ZFHX3 Gene Summary

This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

Gene Name: Zinc Finger Homeobox 3

Chromosome: CHR16: 72816785 -73092534

Locus: 16q22.2-q22.3

WWP2 Gene Summary

This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]

Gene Name: WW Domain Containing E3 Ubiquitin Protein Ligase 2

Chromosome: CHR16: 69796273 -69975643

Locus: 16q22.1

Gene Diseases

The ZFHX3 WWP2 Fusion has been associated with the following diseases:

Disease Name
Lung Squamous Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.