ZFHX3-WWP2 Fusion FISH Probe
The ZFHX3-WWP2 Fusion FISH Probe is used to confirm a fusion of the ZFHX3 and WWP2 genes. The fusion of the ZFHX3 and WWP2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZFHX3-WWP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-RERE | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-REOR | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-REGO | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-REGR | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-REAQ | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-ORRE | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-OROR | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-ORGO | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-GORE | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-GOOR | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-GOGO | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-GOGR | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-GRRE | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-GROR | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-GRGO | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-GRGR | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-AQRE | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-AQOR | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-AQGO | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-AQGR | 20 (40 μL) | 200 μL |
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| ZFHX3-WWP2-20-AQAQ | 20 (40 μL) | 200 μL |
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ZFHX3 Gene Summary
This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Gene Name: Zinc Finger Homeobox 3
Chromosome: CHR16: 72816785 -73092534
Locus: 16q22.2-q22.3
WWP2 Gene Summary
This gene encodes a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. The encoded protein contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 10. [provided by RefSeq, Jul 2012]
Gene Name: WW Domain Containing E3 Ubiquitin Protein Ligase 2
Chromosome: CHR16: 69796273 -69975643
Locus: 16q22.1
Gene Diseases
The ZFHX3 WWP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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