ZFAT-TG Fusion FISH Probe
The ZFAT-TG Fusion FISH Probe is used to confirm a fusion of the ZFAT and TG genes. The fusion of the ZFAT and TG genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZFAT-TG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-RERE | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-REOR | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-REGO | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-REGR | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-REAQ | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-ORRE | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-OROR | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-ORGO | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-GORE | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-GOOR | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-GOGO | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-GOGR | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-GRRE | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-GROR | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-GRGO | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-GRGR | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-AQRE | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-AQOR | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-AQGO | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-AQGR | 20 (40 μL) | 200 μL |
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| ZFAT-TG-20-AQAQ | 20 (40 μL) | 200 μL |
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TG Gene Summary
Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]
Gene Name: Thyroglobulin
Chromosome: CHR8: 133879204 -134147143
Locus: 8q24.22
ZFAT Gene Summary
This gene encodes a protein that likely binds DNA and functions as a transcriptional regulator involved in apoptosis and cell survival. This gene resides in a susceptibility locus for autoimmune thyroid disease (AITD) on chromosome 8q24. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2009]
Gene Name: Zinc Finger And AT-hook Domain Containing
Chromosome: CHR8: 135490030 -135725292
Locus: 8q24.22
Gene Diseases
The ZFAT TG Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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