ZEB2-AKT3 Fusion FISH Probe
The ZEB2-AKT3 Fusion FISH Probe is used to confirm a fusion of the ZEB2 and AKT3 genes. The fusion of the ZEB2 and AKT3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZEB2-AKT3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-RERE | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-REOR | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-REGO | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-REGR | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-REAQ | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-ORRE | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-OROR | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-ORGO | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-GORE | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-GOOR | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-GOGO | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-GOGR | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-GRRE | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-GROR | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-GRGO | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-GRGR | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-AQRE | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-AQOR | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-AQGO | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-AQGR | 20 (40 μL) | 200 μL |
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| ZEB2-AKT3-20-AQAQ | 20 (40 μL) | 200 μL |
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ZEB2 Gene Summary
The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jan 2010]
Gene Name: Zinc Finger E-box Binding Homeobox 2
Chromosome: CHR2: 145141941 -145277958
Locus: 2q22.3
AKT3 Gene Summary
The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Name: AKT Serine/threonine Kinase 3
Chromosome: CHR1: 243651534 -244006584
Locus: 1q43-q44
Gene Diseases
The ZEB2 AKT3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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