ZCRB1-LIMA1 Fusion FISH Probe
The ZCRB1-LIMA1 Fusion FISH Probe is used to confirm a fusion of the ZCRB1 and LIMA1 genes. The fusion of the ZCRB1 and LIMA1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ZCRB1-LIMA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-RERE | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-REOR | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-REGO | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-REGR | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-OROR | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-GORE | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-GROR | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| ZCRB1-LIMA1-20-AQAQ | 20 (40 μL) | 200 μL |
|
LIMA1 Gene Summary
This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]
Gene Name: LIM Domain And Actin Binding 1
Chromosome: CHR12: 50569562 -50677353
Locus: 12q13.12
ZCRB1 Gene Summary
Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]
Gene Name: Zinc Finger CCHC-type And RNA Binding Motif Containing 1
Chromosome: CHR12: 42705887 -42719932
Locus: 12q12
Gene Diseases
The ZCRB1 LIMA1 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|