ZCCHC8-PTPN12 Fusion FISH Probe
The ZCCHC8-PTPN12 Fusion FISH Probe is used to confirm a fusion of the ZCCHC8 and PTPN12 genes. The fusion of the ZCCHC8 and PTPN12 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZCCHC8-PTPN12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-RERE | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-REOR | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-REGO | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-REGR | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-REAQ | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-ORRE | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-OROR | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-ORGO | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-GORE | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-GOOR | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-GOGO | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-GOGR | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-GRRE | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-GROR | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-GRGO | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-GRGR | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-AQRE | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-AQOR | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-AQGO | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-AQGR | 20 (40 μL) | 200 μL |
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| ZCCHC8-PTPN12-20-AQAQ | 20 (40 μL) | 200 μL |
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PTPN12 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 12
Chromosome: CHR7: 77166772 -77269388
Locus: 7q11.23
ZCCHC8 Gene Summary
This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]
Gene Name: Zinc Finger CCHC-type Containing 8
Chromosome: CHR12: 122956145 -122985543
Locus: 12q24.31
Gene Diseases
The ZCCHC8 PTPN12 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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