ZC3HC1-ADAM22 Fusion FISH Probe
The ZC3HC1-ADAM22 Fusion FISH Probe is used to confirm a fusion of the ZC3HC1 and ADAM22 genes. The fusion of the ZC3HC1 and ADAM22 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ZC3HC1-ADAM22-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-RERE | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-REOR | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-REGO | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-REGR | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-REAQ | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-ORRE | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-OROR | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-ORGO | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-ORAQ | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-GORE | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-GOOR | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-GOGO | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-GOGR | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-GOAQ | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-GRRE | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-GROR | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-GRGO | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-GRGR | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-GRAQ | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-AQRE | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-AQOR | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-AQGO | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-AQGR | 20 (40 μL) | 200 μL |
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| ZC3HC1-ADAM22-20-AQAQ | 20 (40 μL) | 200 μL |
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ZC3HC1 Gene Summary
This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]
Gene Name: Zinc Finger C3HC-type Containing 1
Chromosome: CHR7: 129658125 -129691233
Locus: 7q32.2
ADAM22 Gene Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
Gene Name: ADAM Metallopeptidase Domain 22
Chromosome: CHR7: 87563565 -87832204
Locus: 7q21.12
Gene Diseases
The ZC3HC1 ADAM22 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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