YWHAG-OPA3 Fusion FISH Probe
The YWHAG-OPA3 Fusion FISH Probe is used to confirm a fusion of the YWHAG and OPA3 genes. The fusion of the YWHAG and OPA3 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| YWHAG-OPA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-RERE | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-REOR | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-REGO | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-REGR | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-REAQ | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-ORRE | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-OROR | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-ORGO | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-ORAQ | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-GORE | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-GOOR | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-GOGO | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-GOGR | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-GOAQ | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-GRRE | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-GROR | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-GRGO | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-GRGR | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-GRAQ | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-AQRE | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-AQOR | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-AQGO | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-AQGR | 20 (40 μL) | 200 μL |
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| YWHAG-OPA3-20-AQAQ | 20 (40 μL) | 200 μL |
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YWHAG Gene Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase Activation Protein Gamma
Chromosome: CHR7: 75956107 -75988342
Locus: 7q11.23
OPA3 Gene Summary
The mouse ortholog of this protein co-purifies with the mitochondrial inner membrane. Mutations in this gene have been shown to result in 3-methylglutaconic aciduria type III and autosomal dominant optic atrophy and cataract. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Gene Name: OPA3, Outer Mitochondrial Membrane Lipid Metabolism Regulator
Chromosome: CHR19: 46031024 -46088122
Locus: 19q13.32
Gene Diseases
The YWHAG OPA3 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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