YWHAE-INPP5K Fusion FISH Probe
The YWHAE-INPP5K Fusion FISH Probe is used to confirm a fusion of the YWHAE and INPP5K genes. The fusion of the YWHAE and INPP5K genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| YWHAE-INPP5K-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-RERE | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-REOR | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-REGO | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-REGR | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-REAQ | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-ORRE | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-OROR | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-ORGO | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-ORAQ | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-GORE | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-GOOR | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-GOGO | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-GOGR | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-GOAQ | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-GRRE | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-GROR | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-GRGO | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-GRGR | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-GRAQ | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-AQRE | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-AQOR | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-AQGO | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-AQGR | 20 (40 μL) | 200 μL |
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| YWHAE-INPP5K-20-AQAQ | 20 (40 μL) | 200 μL |
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YWHAE Gene Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase Activation Protein Epsilon
Chromosome: CHR17: 1247833 -1303556
Locus: 17p13.3
INPP5K Gene Summary
This gene encodes a protein with 5-phosphatase activity toward polyphosphate inositol. The protein localizes to the cytosol in regions lacking actin stress fibers. It is thought that this protein may negatively regulate the actin cytoskeleton. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2008]
Gene Name: Inositol Polyphosphate-5-phosphatase K
Chromosome: CHR17: 1397870 -1420182
Locus: 17p13.3
Gene Diseases
The YWHAE INPP5K Fusion has been associated with the following diseases:
| Disease Name |
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| Colon Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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