YWHAE-GCGR Fusion FISH Probe
The YWHAE-GCGR Fusion FISH Probe is used to confirm a fusion of the YWHAE and GCGR genes. The fusion of the YWHAE and GCGR genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| YWHAE-GCGR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-RERE | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-REOR | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-REGO | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-REGR | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-REAQ | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-ORRE | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-OROR | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-ORGO | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-ORAQ | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-GORE | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-GOOR | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-GOGO | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-GOGR | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-GOAQ | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-GRRE | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-GROR | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-GRGO | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-GRGR | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-GRAQ | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-AQRE | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-AQOR | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-AQGO | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-AQGR | 20 (40 μL) | 200 μL |
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| YWHAE-GCGR-20-AQAQ | 20 (40 μL) | 200 μL |
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GCGR Gene Summary
The protein encoded by this gene is a glucagon receptor that is important in controlling blood glucose levels. Defects in this gene are a cause of non-insulin-dependent diabetes mellitus (NIDDM).[provided by RefSeq, Jan 2010]
Gene Name: Glucagon Receptor
Chromosome: CHR17: 79762009 -79771889
Locus: 17q25.3
YWHAE Gene Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase Activation Protein Epsilon
Chromosome: CHR17: 1247833 -1303556
Locus: 17p13.3
Gene Diseases
The YWHAE GCGR Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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