YTHDF2-EYA3 Fusion FISH Probe
The YTHDF2-EYA3 Fusion FISH Probe is used to confirm a fusion of the YTHDF2 and EYA3 genes. The fusion of the YTHDF2 and EYA3 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| YTHDF2-EYA3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-RERE | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-REOR | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-REGO | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-REGR | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-REAQ | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-ORRE | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-OROR | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-ORGO | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-ORAQ | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-GORE | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-GOOR | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-GOGO | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-GOGR | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-GOAQ | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-GRRE | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-GROR | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-GRGO | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-GRGR | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-GRAQ | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-AQRE | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-AQOR | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-AQGO | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-AQGR | 20 (40 μL) | 200 μL |
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| YTHDF2-EYA3-20-AQAQ | 20 (40 μL) | 200 μL |
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EYA3 Gene Summary
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may act as a transcriptional activator and have a role during development. It can act as a mediator of chemoresistance and cell survival in Ewing sarcoma cells, where this gene is up-regulated via a micro-RNA that binds to the 3' UTR of the transcript. A similar protein in mice acts as a transcriptional activator. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: EYA Transcriptional Coactivator And Phosphatase 3
Chromosome: CHR1: 28296854 -28415148
Locus: 1p35.3
YTHDF2 Gene Summary
This gene encodes a member of the YTH (YT521-B homology) superfamily containing YTH domain. The YTH domain is typical for the eukaryotes and is particularly abundant in plants. The YTH domain is usually located in the middle of the protein sequence and may function in binding to RNA. In addition to a YTH domain, this protein has a proline rich region which may be involved in signal transduction. An Alu-rich domain has been identified in one of the introns of this gene, which is thought to be associated with human longevity. In addition, reciprocal translocations between this gene and the Runx1 (AML1) gene on chromosome 21 has been observed in patients with acute myeloid leukemia. This gene was initially mapped to chromosome 14, which was later turned out to be a pseudogene. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Oct 2012]
Gene Name: YTH N6-methyladenosine RNA Binding Protein 2
Chromosome: CHR1: 29063132 -29096287
Locus: 1p35.3
Gene Diseases
The YTHDF2 EYA3 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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