YPEL2-BPTF Fusion FISH Probe
The YPEL2-BPTF Fusion FISH Probe is used to confirm a fusion of the YPEL2 and BPTF genes. The fusion of the YPEL2 and BPTF genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| YPEL2-BPTF-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-RERE | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-REOR | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-REGO | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-REGR | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-REAQ | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-ORRE | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-OROR | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-ORGO | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-ORAQ | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-GORE | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-GOOR | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-GOGO | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-GOGR | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-GOAQ | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-GRRE | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-GROR | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-GRGO | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-GRGR | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-GRAQ | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-AQRE | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-AQOR | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-AQGO | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-AQGR | 20 (40 μL) | 200 μL |
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| YPEL2-BPTF-20-AQAQ | 20 (40 μL) | 200 μL |
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BPTF Gene Summary
This gene was identified by the reactivity of its encoded protein to a monoclonal antibody prepared against brain homogenates from patients with Alzheimer's disease. Analysis of the original protein (fetal Alz-50 reactive clone 1, or FAC1), identified as an 810 aa protein containing a DNA-binding domain and a zinc finger motif, suggested it might play a role in the regulation of transcription. High levels of FAC1 were detected in fetal brain and in patients with neurodegenerative diseases. The protein encoded by this gene is actually much larger than originally thought, and it also contains a C-terminal bromodomain characteristic of proteins that regulate transcription during proliferation. The encoded protein is highly similar to the largest subunit of the Drosophila NURF (nucleosome remodeling factor) complex. In Drosophila, the NURF complex, which catalyzes nucleosome sliding on DNA and interacts with sequence-specific transcription factors, is necessary for the chromatin remodeling required for transcription. Two alternative transcripts encoding different isoforms have been described completely. [provided by RefSeq, Jul 2008]
Gene Name: Bromodomain PHD Finger Transcription Factor
Chromosome: CHR17: 65821779 -65980494
Locus: 17q24.2
YPEL2 Gene Summary
The Yippee Like 2 (YPEL2) gene is located on chr17 :57409052-57479095 at 17q22.
Gene Name: Yippee Like 2
Chromosome: CHR17: 57409052 -57479095
Locus: 17q22
Gene Diseases
The YPEL2 BPTF Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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