YARS-ANKRD17 Fusion FISH Probe
The YARS-ANKRD17 Fusion FISH Probe is used to confirm a fusion of the YARS and ANKRD17 genes. The fusion of the YARS and ANKRD17 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| YARS-ANKRD17-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-RERE | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-REOR | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-REGO | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-REGR | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-REAQ | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-ORRE | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-OROR | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-ORGO | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-ORAQ | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-GORE | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-GOOR | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-GOGO | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-GOGR | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-GOAQ | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-GRRE | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-GROR | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-GRGO | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-GRGR | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-GRAQ | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-AQRE | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-AQOR | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-AQGO | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-AQGR | 20 (40 μL) | 200 μL |
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| YARS-ANKRD17-20-AQAQ | 20 (40 μL) | 200 μL |
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YARS Gene Summary
Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Tyrosyl-tRNA synthetase belongs to the class I tRNA synthetase family. Cytokine activities have also been observed for the human tyrosyl-tRNA synthetase, after it is split into two parts, an N-terminal fragment that harbors the catalytic site and a C-terminal fragment found only in the mammalian enzyme. The N-terminal fragment is an interleukin-8-like cytokine, whereas the released C-terminal fragment is an EMAP II-like cytokine. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosyl-tRNA Synthetase
Chromosome: CHR1: 33240839 -33283633
Locus: 1p35.1
ANKRD17 Gene Summary
The protein encoded by this gene belongs to the family of ankyrin repeat-containing proteins, and contains two distinct arrays of ankyrin repeats in its amino-terminal region, one with 15 ankyrin repeats, and the other with 10 ankyrin repeats. It also contains a nuclear export signal, nuclear localization signal, and a cyclin-binding RXL motif. Localization of this protein to the nucleus has been shown experimentally, and interactions between this protein and cyclin-dependent kinase 2 have been observed. It has been suggested that this protein plays a role in both DNA replication and in both anti-viral and anti-bacterial innate immune pathways. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: Ankyrin Repeat Domain 17
Chromosome: CHR4: 73940501 -74124502
Locus: 4q13.3
Gene Diseases
The YARS ANKRD17 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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