YAP1-STIM1 Fusion FISH Probe
The YAP1-STIM1 Fusion FISH Probe is used to confirm a fusion of the YAP1 and STIM1 genes. The fusion of the YAP1 and STIM1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| YAP1-STIM1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-RERE | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-REOR | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-REGO | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-REGR | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-REAQ | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-ORRE | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-OROR | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-ORGO | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-ORAQ | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-GORE | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-GOOR | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-GOGO | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-GOGR | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-GOAQ | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-GRRE | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-GROR | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-GRGO | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-GRGR | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-GRAQ | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-AQRE | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-AQOR | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-AQGO | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-AQGR | 20 (40 μL) | 200 μL |
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| YAP1-STIM1-20-AQAQ | 20 (40 μL) | 200 μL |
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STIM1 Gene Summary
This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. Mutations in this gene are associated with fatal classic Kaposi sarcoma, immunodeficiency due to defects in store-operated calcium entry (SOCE) in fibroblasts, ectodermal dysplasia and tubular aggregate myopathy. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Gene Name: Stromal Interaction Molecule 1
Chromosome: CHR11: 3876932 -4114440
Locus: 11p15.4
YAP1 Gene Summary
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
Gene Name: Yes Associated Protein 1
Chromosome: CHR11: 101981191 -102104154
Locus: 11q22.1
Gene Diseases
The YAP1 STIM1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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