YAP1-MRPL48 Fusion FISH Probe
The YAP1-MRPL48 Fusion FISH Probe is used to confirm a fusion of the YAP1 and MRPL48 genes. The fusion of the YAP1 and MRPL48 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| YAP1-MRPL48-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-RERE | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-REOR | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-REGO | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-REGR | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-REAQ | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-ORRE | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-OROR | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-ORGO | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-ORAQ | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-GORE | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-GOOR | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-GOGO | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-GOGR | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-GOAQ | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-GRRE | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-GROR | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-GRGO | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-GRGR | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-GRAQ | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-AQRE | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-AQOR | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-AQGO | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-AQGR | 20 (40 μL) | 200 μL |
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| YAP1-MRPL48-20-AQAQ | 20 (40 μL) | 200 μL |
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YAP1 Gene Summary
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
Gene Name: Yes Associated Protein 1
Chromosome: CHR11: 101981191 -102104154
Locus: 11q22.1
MRPL48 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 6p. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene. [provided by RefSeq, Jan 2016]
Gene Name: Mitochondrial Ribosomal Protein L48
Chromosome: CHR11: 73498916 -73575656
Locus: 11q13.4
Gene Diseases
The YAP1 MRPL48 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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