YAP1-MAML2 Fusion FISH Probe
The YAP1-MAML2 Fusion FISH Probe is used to confirm a fusion of the YAP1 and MAML2 genes. The fusion of the YAP1 and MAML2 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| YAP1-MAML2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-RERE | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-REOR | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-REGO | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-REGR | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-REAQ | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-ORRE | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-OROR | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-ORGO | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-ORAQ | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-GORE | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-GOOR | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-GOGO | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-GOGR | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-GOAQ | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-GRRE | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-GROR | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-GRGO | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-GRGR | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-GRAQ | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-AQRE | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-AQOR | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-AQGO | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-AQGR | 20 (40 μL) | 200 μL |
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| YAP1-MAML2-20-AQAQ | 20 (40 μL) | 200 μL |
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YAP1 Gene Summary
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]
Gene Name: Yes Associated Protein 1
Chromosome: CHR11: 101981191 -102104154
Locus: 11q22.1
MAML2 Gene Summary
The protein encoded by this gene is a member of the Mastermind-like family of proteins. All family members are proline and glutamine-rich, and contain a conserved basic domain that binds the ankyrin repeat domain of the intracellular domain of the Notch receptors (ICN1-4) in their N-terminus, and a transcriptional activation domain in their C-terminus. This protein binds to an extended groove that is formed by the interaction of CBF1, Suppressor of Hairless, LAG-1 (CSL) with ICN, and positively regulates Notch signaling. High levels of expression of this gene have been observed in several B cell-derived lymphomas. Translocations resulting in fusion proteins with both CRTC1 and CRTC3 have been implicated in the development of mucoepidermoid carcinomas, while a translocation event with CXCR4 has been linked with chronic lymphocytic leukemia (CLL). Copy number variation in the polyglutamine tract has been observed. [provided by RefSeq, Jan 2015]
Gene Name: Mastermind Like Transcriptional Coactivator 2
Chromosome: CHR11: 95711439 -96076344
Locus: 11q21
Gene Diseases
The YAP1 MAML2 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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