YAF2-SYT1 Fusion FISH Probe
The YAF2-SYT1 Fusion FISH Probe is used to confirm a fusion of the YAF2 and SYT1 genes. The fusion of the YAF2 and SYT1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| YAF2-SYT1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-RERE | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-REOR | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-REGO | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-REGR | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-REAQ | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-ORRE | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-OROR | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-ORGO | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-ORAQ | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-GORE | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-GOOR | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-GOGO | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-GOGR | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-GOAQ | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-GRRE | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-GROR | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-GRGO | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-GRGR | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-GRAQ | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-AQRE | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-AQOR | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-AQGO | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-AQGR | 20 (40 μL) | 200 μL |
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| YAF2-SYT1-20-AQAQ | 20 (40 μL) | 200 μL |
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SYT1 Gene Summary
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]
Gene Name: Synaptotagmin 1
Chromosome: CHR12: 79257772 -79845788
Locus: 12q21.2
YAF2 Gene Summary
This gene encodes a zinc finger containing protein that functions in the regulation of transcription. This protein was identified as an interacting partner of transcriptional repressor protein Yy1, and also interacts with other transcriptional regulators, including Myc and Polycomb. This protein can promote proteolysis of Yy1. Multiple alternatively spliced transcript variants have been found. [provided by RefSeq, Feb 2016]
Gene Name: YY1 Associated Factor 2
Chromosome: CHR12: 42550906 -42632154
Locus: 12q12
Gene Diseases
The YAF2 SYT1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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