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XYLT1-SPN Fusion FISH Probe

The XYLT1-SPN Fusion FISH Probe is used to confirm a fusion of the XYLT1 and SPN genes. The fusion of the XYLT1 and SPN genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
XYLT1-SPN-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
XYLT1-SPN-20-RERE 20 (40 μL) 200 μL
XYLT1-SPN-20-REOR 20 (40 μL) 200 μL
XYLT1-SPN-20-REGO 20 (40 μL) 200 μL
XYLT1-SPN-20-REGR 20 (40 μL) 200 μL
XYLT1-SPN-20-REAQ 20 (40 μL) 200 μL
XYLT1-SPN-20-ORRE 20 (40 μL) 200 μL
XYLT1-SPN-20-OROR 20 (40 μL) 200 μL
XYLT1-SPN-20-ORGO 20 (40 μL) 200 μL
XYLT1-SPN-20-ORAQ 20 (40 μL) 200 μL
XYLT1-SPN-20-GORE 20 (40 μL) 200 μL
XYLT1-SPN-20-GOOR 20 (40 μL) 200 μL
XYLT1-SPN-20-GOGO 20 (40 μL) 200 μL
XYLT1-SPN-20-GOGR 20 (40 μL) 200 μL
XYLT1-SPN-20-GOAQ 20 (40 μL) 200 μL
XYLT1-SPN-20-GRRE 20 (40 μL) 200 μL
XYLT1-SPN-20-GROR 20 (40 μL) 200 μL
XYLT1-SPN-20-GRGO 20 (40 μL) 200 μL
XYLT1-SPN-20-GRGR 20 (40 μL) 200 μL
XYLT1-SPN-20-GRAQ 20 (40 μL) 200 μL
XYLT1-SPN-20-AQRE 20 (40 μL) 200 μL
XYLT1-SPN-20-AQOR 20 (40 μL) 200 μL
XYLT1-SPN-20-AQGO 20 (40 μL) 200 μL
XYLT1-SPN-20-AQGR 20 (40 μL) 200 μL
XYLT1-SPN-20-AQAQ 20 (40 μL) 200 μL

SPN Gene Summary

This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome. [provided by RefSeq, Sep 2017]

Gene Name: Sialophorin

Chromosome: CHR16: 29674299 -29681823

Locus: 16p11.2

XYLT1 Gene Summary

This locus encodes a xylosyltransferase enzyme. The encoded protein catalyzes transfer of UDP-xylose to serine residues of an acceptor protein substrate. This transfer reaction is necessary for biosynthesis of glycosaminoglycan chains. Mutations in this gene have been associated with increased severity of pseudoxanthoma elasticum.[provided by RefSeq, Nov 2009]

Gene Name: Xylosyltransferase 1

Chromosome: CHR16: 17196180 -17564738

Locus: 16p12.3

Gene Diseases

The XYLT1 SPN Fusion has been associated with the following diseases:

Disease Name
Stomach Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.