XYLB-DLEC1 Fusion FISH Probe
The XYLB-DLEC1 Fusion FISH Probe is used to confirm a fusion of the XYLB and DLEC1 genes. The fusion of the XYLB and DLEC1 genes has been associated with Stomach Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| XYLB-DLEC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-RERE | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-REOR | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-REGO | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-REGR | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-REAQ | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-ORRE | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-OROR | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-ORGO | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-GORE | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-GOOR | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-GOGO | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-GOGR | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-GRRE | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-GROR | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-GRGO | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-GRGR | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-AQRE | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-AQOR | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-AQGO | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-AQGR | 20 (40 μL) | 200 μL |
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| XYLB-DLEC1-20-AQAQ | 20 (40 μL) | 200 μL |
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DLEC1 Gene Summary
The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016]
Gene Name: Deleted In Lung And Esophageal Cancer 1
Chromosome: CHR3: 38080695 -38164228
Locus: 3p22.2
XYLB Gene Summary
The protein encoded by this gene shares 22% sequence identity with Hemophilus influenzae xylulokinase, and even higher identity to other gene products in C.elegans (45%) and yeast (31-35%), which are thought to belong to a family of enzymes that include fucokinase, gluconokinase, glycerokinase and xylulokinase. These proteins play important roles in energy metabolism. [provided by RefSeq, Aug 2009]
Gene Name: Xylulokinase
Chromosome: CHR3: 38388250 -38456467
Locus: 3p22.2
Gene Diseases
The XYLB DLEC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Stomach Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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