XRN2-RIN2 Fusion FISH Probe
The XRN2-RIN2 Fusion FISH Probe is used to confirm a fusion of the XRN2 and RIN2 genes. The fusion of the XRN2 and RIN2 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| XRN2-RIN2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-RERE | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-REOR | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-REGO | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-REGR | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-REAQ | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-ORRE | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-OROR | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-ORGO | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-ORAQ | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-GORE | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-GOOR | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-GOGO | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-GOGR | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-GOAQ | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-GRRE | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-GROR | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-GRGO | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-GRGR | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-GRAQ | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-AQRE | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-AQOR | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-AQGO | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-AQGR | 20 (40 μL) | 200 μL |
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| XRN2-RIN2-20-AQAQ | 20 (40 μL) | 200 μL |
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XRN2 Gene Summary
This gene encodes a 5'-3' exonuclease that promotes transcription termination at cotranscriptional cleavage sites. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: 5'-3' Exoribonuclease 2
Chromosome: CHR20: 21283941 -21370463
Locus: 20p11.22
RIN2 Gene Summary
The RAB5 protein is a small GTPase involved in membrane trafficking in the early endocytic pathway. The protein encoded by this gene binds the GTP-bound form of the RAB5 protein preferentially over the GDP-bound form, and functions as a guanine nucleotide exchange factor for RAB5. The encoded protein is found primarily as a tetramer in the cytoplasm and does not bind other members of the RAB family. Mutations in this gene cause macrocephaly alopecia cutis laxa and scoliosis (MACS) syndrome, an elastic tissue disorder, as well as the related connective tissue disorder, RIN2 syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2011]
Gene Name: Ras And Rab Interactor 2
Chromosome: CHR20: 19867164 -19983103
Locus: 20p11.23
Gene Diseases
The XRN2 RIN2 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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