XRN1-PRKCE Fusion FISH Probe
The XRN1-PRKCE Fusion FISH Probe is used to confirm a fusion of the XRN1 and PRKCE genes. The fusion of the XRN1 and PRKCE genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| XRN1-PRKCE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-RERE | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-REOR | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-REGO | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-REGR | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-REAQ | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-ORRE | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-OROR | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-ORGO | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-ORAQ | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-GORE | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-GOOR | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-GOGO | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-GOGR | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-GOAQ | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-GRRE | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-GROR | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-GRGO | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-GRGR | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-GRAQ | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-AQRE | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-AQOR | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-AQGO | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-AQGR | 20 (40 μL) | 200 μL |
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| XRN1-PRKCE-20-AQAQ | 20 (40 μL) | 200 μL |
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PRKCE Gene Summary
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macrophages and may also play a role in controlling anxiety-like behavior. [provided by RefSeq, Jul 2008]
Gene Name: Protein Kinase C Epsilon
Chromosome: CHR2: 45879042 -46415129
Locus: 2p21
XRN1 Gene Summary
This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: 5'-3' Exoribonuclease 1
Chromosome: CHR3: 142025448 -142166853
Locus: 3q23
Gene Diseases
The XRN1 PRKCE Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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