XRN1-PIP4K2A Fusion FISH Probe
The XRN1-PIP4K2A Fusion FISH Probe is used to confirm a fusion of the XRN1 and PIP4K2A genes. The fusion of the XRN1 and PIP4K2A genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| XRN1-PIP4K2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-RERE | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-REOR | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-REGO | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-REGR | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-REAQ | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-ORRE | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-OROR | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-ORGO | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-GORE | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-GOOR | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-GOGO | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-GOGR | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-GRRE | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-GROR | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-GRGO | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-GRGR | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-AQRE | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-AQOR | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-AQGO | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-AQGR | 20 (40 μL) | 200 μL |
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| XRN1-PIP4K2A-20-AQAQ | 20 (40 μL) | 200 μL |
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PIP4K2A Gene Summary
Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]
Gene Name: Phosphatidylinositol-5-phosphate 4-kinase Type 2 Alpha
Chromosome: CHR10: 22823765 -23003503
Locus: 10p12.2
XRN1 Gene Summary
This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: 5'-3' Exoribonuclease 1
Chromosome: CHR3: 142025448 -142166853
Locus: 3q23
Gene Diseases
The XRN1 PIP4K2A Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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