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XRN1-PIP4K2A Fusion FISH Probe

The XRN1-PIP4K2A Fusion FISH Probe is used to confirm a fusion of the XRN1 and PIP4K2A genes. The fusion of the XRN1 and PIP4K2A genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
XRN1-PIP4K2A-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-RERE 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-REOR 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-REGO 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-REGR 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-REAQ 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-ORRE 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-OROR 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-ORGO 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-ORAQ 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-GORE 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-GOOR 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-GOGO 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-GOGR 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-GOAQ 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-GRRE 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-GROR 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-GRGO 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-GRGR 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-GRAQ 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-AQRE 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-AQOR 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-AQGO 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-AQGR 20 (40 μL) 200 μL
XRN1-PIP4K2A-20-AQAQ 20 (40 μL) 200 μL

PIP4K2A Gene Summary

Phosphatidylinositol-5,4-bisphosphate, the precursor to second messengers of the phosphoinositide signal transduction pathways, is thought to be involved in the regulation of secretion, cell proliferation, differentiation, and motility. The protein encoded by this gene is one of a family of enzymes capable of catalyzing the phosphorylation of phosphatidylinositol-5-phosphate on the fourth hydroxyl of the myo-inositol ring to form phosphatidylinositol-5,4-bisphosphate. The amino acid sequence of this enzyme does not show homology to other kinases, but the recombinant protein does exhibit kinase activity. This gene is a member of the phosphatidylinositol-5-phosphate 4-kinase family. [provided by RefSeq, Jul 2008]

Gene Name: Phosphatidylinositol-5-phosphate 4-kinase Type 2 Alpha

Chromosome: CHR10: 22823765 -23003503

Locus: 10p12.2

XRN1 Gene Summary

This gene encodes a member of the 5'-3' exonuclease family. The encoded protein may be involved in replication-dependent histone mRNA degradation, and interacts directly with the enhancer of mRNA-decapping protein 4. In addition to mRNA metabolism, a similar protein in yeast has been implicated in a variety of nuclear and cytoplasmic functions, including homologous recombination, meiosis, telomere maintenance, and microtubule assembly. Mutations in this gene are associated with osteosarcoma, suggesting that the encoded protein may also play a role in bone formation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Gene Name: 5'-3' Exoribonuclease 1

Chromosome: CHR3: 142025448 -142166853

Locus: 3q23

Gene Diseases

The XRN1 PIP4K2A Fusion has been associated with the following diseases:

Disease Name
Breast Invasive Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.