XRCC5-ABCB1 Fusion FISH Probe
The XRCC5-ABCB1 Fusion FISH Probe is used to confirm a fusion of the XRCC5 and ABCB1 genes. The fusion of the XRCC5 and ABCB1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| XRCC5-ABCB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-RERE | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-REOR | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-REGO | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-REGR | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-REAQ | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-ORRE | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-OROR | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-ORGO | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-GORE | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-GOOR | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-GOGO | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-GOGR | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-GRRE | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-GROR | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-GRGO | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-GRGR | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-AQRE | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-AQOR | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-AQGO | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-AQGR | 20 (40 μL) | 200 μL |
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| XRCC5-ABCB1-20-AQAQ | 20 (40 μL) | 200 μL |
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ABCB1 Gene Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Gene Name: ATP Binding Cassette Subfamily B Member 1
Chromosome: CHR7: 87133178 -87342639
Locus: 7q21.12
XRCC5 Gene Summary
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
Gene Name: X-ray Repair Cross Complementing 5
Chromosome: CHR2: 216974019 -217071016
Locus: 2q35
Gene Diseases
The XRCC5 ABCB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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