XPO5-MRPS10 Fusion FISH Probe
The XPO5-MRPS10 Fusion FISH Probe is used to confirm a fusion of the XPO5 and MRPS10 genes. The fusion of the XPO5 and MRPS10 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| XPO5-MRPS10-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-RERE | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-REOR | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-REGO | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-REGR | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-OROR | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-GORE | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-GROR | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| XPO5-MRPS10-20-AQAQ | 20 (40 μL) | 200 μL |
|
MRPS10 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S10P family. Pseudogenes corresponding to this gene are found on chromosomes 1q, 3p, and 9p. [provided by RefSeq, Jul 2008]
Gene Name: Mitochondrial Ribosomal Protein S10
Chromosome: CHR6: 42174538 -42185633
Locus: 6p21.1
XPO5 Gene Summary
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]
Gene Name: Exportin 5
Chromosome: CHR6: 43490067 -43543812
Locus: 6p21.1
Gene Diseases
The XPO5 MRPS10 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Kidney Renal Clear Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|