XPA-CORO2A Fusion FISH Probe
The XPA-CORO2A Fusion FISH Probe is used to confirm a fusion of the XPA and CORO2A genes. The fusion of the XPA and CORO2A genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| XPA-CORO2A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-RERE | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-REOR | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-REGO | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-REGR | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-REAQ | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-ORRE | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-OROR | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-ORGO | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-ORAQ | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-GORE | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-GOOR | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-GOGO | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-GOGR | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-GOAQ | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-GRRE | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-GROR | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-GRGO | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-GRGR | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-GRAQ | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-AQRE | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-AQOR | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-AQGO | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-AQGR | 20 (40 μL) | 200 μL |
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| XPA-CORO2A-20-AQAQ | 20 (40 μL) | 200 μL |
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CORO2A Gene Summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Gene Name: Coronin 2A
Chromosome: CHR9: 100883256 -100954956
Locus: 9q22.33
XPA Gene Summary
This gene encodes a zinc finger protein plays a central role in nucleotide excision repair (NER), a specialized type of DNA repair. NER is responsible for repair of UV radiation-induced photoproducts and DNA adducts induced by chemical carcinogens and chemotherapeutic drugs. The encoded protein interacts with DNA and several NER proteins, acting as a scaffold to assemble the NER incision complex at sites of DNA damage. Mutations in this gene cause Xeroderma pigmentosum complementation group A (XP-A), an autosomal recessive skin disorder featuring hypersensitivity to sunlight and increased risk for skin cancer. [provided by RefSeq, Aug 2017]
Gene Name: XPA, DNA Damage Recognition And Repair Factor
Chromosome: CHR9: 100437190 -100459691
Locus: 9q22.33
Gene Diseases
The XPA CORO2A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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