XBP1-UTRN Fusion FISH Probe
The XBP1-UTRN Fusion FISH Probe is used to confirm a fusion of the XBP1 and UTRN genes. The fusion of the XBP1 and UTRN genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| XBP1-UTRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-RERE | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-REOR | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-REGO | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-REGR | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-REAQ | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-ORRE | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-OROR | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-ORGO | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-GORE | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-GOOR | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-GOGO | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-GOGR | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-GRRE | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-GROR | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-GRGO | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-GRGR | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-AQRE | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-AQOR | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-AQGO | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-AQGR | 20 (40 μL) | 200 μL |
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| XBP1-UTRN-20-AQAQ | 20 (40 μL) | 200 μL |
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UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
XBP1 Gene Summary
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]
Gene Name: X-box Binding Protein 1
Chromosome: CHR22: 29190547 -29196560
Locus: 22q12
Gene Diseases
The XBP1 UTRN Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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