WWTR1-ESRRG Fusion FISH Probe
The WWTR1-ESRRG Fusion FISH Probe is used to confirm a fusion of the WWTR1 and ESRRG genes. The fusion of the WWTR1 and ESRRG genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WWTR1-ESRRG-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-RERE | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-REOR | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-REGO | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-REGR | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-REAQ | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-ORRE | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-OROR | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-ORGO | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-ORAQ | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-GORE | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-GOOR | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-GOGO | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-GOGR | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-GOAQ | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-GRRE | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-GROR | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-GRGO | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-GRGR | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-GRAQ | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-AQRE | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-AQOR | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-AQGO | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-AQGR | 20 (40 μL) | 200 μL |
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| WWTR1-ESRRG-20-AQAQ | 20 (40 μL) | 200 μL |
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ESRRG Gene Summary
This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
Gene Name: Estrogen Related Receptor Gamma
Chromosome: CHR1: 216676587 -217311097
Locus: 1q41
WWTR1 Gene Summary
The WW Domain Containing Transcription Regulator 1 (WWTR1) gene is located on chr3 :149235021-149421060 at 3q25.1.
Gene Name: WW Domain Containing Transcription Regulator 1
Chromosome: CHR3: 149235021 -149421060
Locus: 3q25.1
Gene Diseases
The WWTR1 ESRRG Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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