WWP1-LRRCC1 Fusion FISH Probe
The WWP1-LRRCC1 Fusion FISH Probe is used to confirm a fusion of the WWP1 and LRRCC1 genes. The fusion of the WWP1 and LRRCC1 genes has been associated with Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WWP1-LRRCC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-RERE | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-REOR | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-REGO | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-REGR | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-REAQ | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-ORRE | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-OROR | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-ORGO | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-GORE | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-GOOR | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-GOGO | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-GOGR | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-GRRE | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-GROR | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-GRGO | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-GRGR | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-AQRE | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-AQOR | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-AQGO | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-AQGR | 20 (40 μL) | 200 μL |
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| WWP1-LRRCC1-20-AQAQ | 20 (40 μL) | 200 μL |
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WWP1 Gene Summary
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
Gene Name: WW Domain Containing E3 Ubiquitin Protein Ligase 1
Chromosome: CHR8: 87354993 -87480178
Locus: 8q21.3
LRRCC1 Gene Summary
This gene encodes a centrosomal protein that maintains the structural integrity of the centrosome and plays a key role in mitotic spindle formation. The encoded protein contains an N-terminal leucine-rich repeat domain and a C-terminal coiled-coil domain. It associates with the centrosome throughout the cell cycle and accumulates on the mitotic centrosome. [provided by RefSeq, Mar 2017]
Gene Name: Leucine Rich Repeat And Coiled-coil Centrosomal Protein 1
Chromosome: CHR8: 86019322 -86058314
Locus: 8q21.2
Gene Diseases
The WWP1 LRRCC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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