WWP1-CPB2 Fusion FISH Probe
The WWP1-CPB2 Fusion FISH Probe is used to confirm a fusion of the WWP1 and CPB2 genes. The fusion of the WWP1 and CPB2 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WWP1-CPB2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-RERE | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-REOR | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-REGO | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-REGR | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-REAQ | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-ORRE | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-OROR | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-ORGO | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-ORAQ | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-GORE | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-GOOR | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-GOGO | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-GOGR | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-GOAQ | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-GRRE | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-GROR | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-GRGO | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-GRGR | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-GRAQ | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-AQRE | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-AQOR | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-AQGO | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-AQGR | 20 (40 μL) | 200 μL |
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| WWP1-CPB2-20-AQAQ | 20 (40 μL) | 200 μL |
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CPB2 Gene Summary
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Gene Name: Carboxypeptidase B2
Chromosome: CHR13: 46627321 -46679211
Locus: 13q14.13
WWP1 Gene Summary
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 4 tandem WW domains and a HECT (homologous to the E6-associated protein carboxyl terminus) domain. The encoded protein belongs to a family of NEDD4-like proteins, which are E3 ubiquitin-ligase molecules and regulate key trafficking decisions, including targeting of proteins to proteosomes or lysosomes. Alternative splicing of this gene generates at least 6 transcript variants; however, the full length nature of these transcripts has not been defined. [provided by RefSeq, Jul 2008]
Gene Name: WW Domain Containing E3 Ubiquitin Protein Ligase 1
Chromosome: CHR8: 87354993 -87480178
Locus: 8q21.3
Gene Diseases
The WWP1 CPB2 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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