WTAP-SOCS2 Fusion FISH Probe
The WTAP-SOCS2 Fusion FISH Probe is used to confirm a fusion of the WTAP and SOCS2 genes. The fusion of the WTAP and SOCS2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WTAP-SOCS2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-RERE | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-REOR | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-REGO | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-REGR | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-REAQ | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-ORRE | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-OROR | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-ORGO | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-ORAQ | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-GORE | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-GOOR | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-GOGO | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-GOGR | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-GOAQ | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-GRRE | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-GROR | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-GRGO | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-GRGR | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-GRAQ | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-AQRE | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-AQOR | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-AQGO | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-AQGR | 20 (40 μL) | 200 μL |
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| WTAP-SOCS2-20-AQAQ | 20 (40 μL) | 200 μL |
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SOCS2 Gene Summary
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Name: Suppressor Of Cytokine Signaling 2
Chromosome: CHR12: 93963597 -93969978
Locus: 12q22
WTAP Gene Summary
The Wilms tumor suppressor gene WT1 appears to play a role in both transcriptional and posttranscriptional regulation of certain cellular genes. This gene encodes a WT1-associating protein, which is a ubiquitously expressed nuclear protein. Like WT1 protein, this protein is localized throughout the nucleoplasm as well as in speckles and partially colocalizes with splicing factors. Alternative splicing of this gene results in several transcript variants encoding three different isoforms. [provided by RefSeq, Jul 2012]
Gene Name: WT1 Associated Protein
Chromosome: CHR6: 160148151 -160177351
Locus: 6q25.3
Gene Diseases
The WTAP SOCS2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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