WSB2-RFC5 Fusion FISH Probe
The WSB2-RFC5 Fusion FISH Probe is used to confirm a fusion of the WSB2 and RFC5 genes. The fusion of the WSB2 and RFC5 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WSB2-RFC5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-RERE | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-REOR | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-REGO | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-REGR | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-REAQ | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-ORRE | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-OROR | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-ORGO | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-ORAQ | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-GORE | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-GOOR | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-GOGO | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-GOGR | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-GOAQ | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-GRRE | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-GROR | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-GRGO | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-GRGR | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-GRAQ | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-AQRE | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-AQOR | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-AQGO | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-AQGR | 20 (40 μL) | 200 μL |
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| WSB2-RFC5-20-AQAQ | 20 (40 μL) | 200 μL |
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RFC5 Gene Summary
This gene encodes the smallest subunit of the replication factor C complex, which consists of five distinct subunits (140, 40, 38, 37, and 36 kDa) and is required for DNA replication. This subunit interacts with the C-terminal region of proliferating cell nuclear antigen and is required to open and load proliferating cell nuclear antigen onto DNA during S phase. It is a member of the AAA+ (ATPases associated with various cellular activities) ATPase family and forms a core complex with the 38 and 40 kDa subunits that possesses DNA-dependent ATPase activity. A related pseudogene has been identified on chromosome 9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Gene Name: Replication Factor C Subunit 5
Chromosome: CHR12: 118454505 -118470042
Locus: 12q24.23
WSB2 Gene Summary
This gene encodes a member of the WD-protein subfamily. The encoded protein contains five WD-repeats spanning most of the protein and an SOCS box in the C-terminus. The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]
Gene Name: WD Repeat And SOCS Box Containing 2
Chromosome: CHR12: 118470491 -118498951
Locus: 12q24.23
Gene Diseases
The WSB2 RFC5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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