WSB1-NBR1 Fusion FISH Probe
The WSB1-NBR1 Fusion FISH Probe is used to confirm a fusion of the WSB1 and NBR1 genes. The fusion of the WSB1 and NBR1 genes has been associated with Acute Myeloid Leukemia. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WSB1-NBR1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-RERE | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-REOR | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-REGO | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-REGR | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-REAQ | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-ORRE | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-OROR | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-ORGO | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-ORAQ | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-GORE | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-GOOR | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-GOGO | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-GOGR | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-GOAQ | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-GRRE | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-GROR | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-GRGO | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-GRGR | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-GRAQ | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-AQRE | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-AQOR | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-AQGO | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-AQGR | 20 (40 μL) | 200 μL |
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| WSB1-NBR1-20-AQAQ | 20 (40 μL) | 200 μL |
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NBR1 Gene Summary
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Gene Name: NBR1, Autophagy Cargo Receptor
Chromosome: CHR17: 41322497 -41363707
Locus: 17q21.31
WSB1 Gene Summary
This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: WD Repeat And SOCS Box Containing 1
Chromosome: CHR17: 25621105 -25640645
Locus: 17q11.1
Gene Diseases
The WSB1 NBR1 Fusion has been associated with the following diseases:
| Disease Name |
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| Acute Myeloid Leukemia |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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