WRNIP1-SERPINB6 Fusion FISH Probe
The WRNIP1-SERPINB6 Fusion FISH Probe is used to confirm a fusion of the WRNIP1 and SERPINB6 genes. The fusion of the WRNIP1 and SERPINB6 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WRNIP1-SERPINB6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-RERE | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-REOR | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-REGO | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-REGR | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-REAQ | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-ORRE | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-OROR | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-ORGO | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-ORAQ | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-GORE | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-GOOR | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-GOGO | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-GOGR | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-GOAQ | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-GRRE | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-GROR | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-GRGO | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-GRGR | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-GRAQ | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-AQRE | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-AQOR | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-AQGO | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-AQGR | 20 (40 μL) | 200 μL |
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| WRNIP1-SERPINB6-20-AQAQ | 20 (40 μL) | 200 μL |
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SERPINB6 Gene Summary
The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
Gene Name: Serpin Family B Member 6
Chromosome: CHR6: 2948392 -2972399
Locus: 6p25.2
WRNIP1 Gene Summary
Werner's syndrome is a rare autosomal recessive disorder characterized by accelerated aging that is caused by defects in the Werner syndrome ATP-dependent helicase gene (WRN). The protein encoded by this gene interacts with the exonuclease-containing N-terminal portion of the Werner protein. This protein has a ubiquitin-binding zinc-finger domain in the N-terminus, an ATPase domain, and two leucine zipper motifs in the C-terminus. It has sequence similarity to replication factor C family proteins and is conserved from E. coli to human. This protein likely accumulates at sites of DNA damage by interacting with polyubiquinated proteins and also binds to DNA polymerase delta and increases the initiation frequency of DNA polymerase delta-mediated DNA synthesis. This protein also interacts with nucleoporins at nuclear pore complexes. Two transcript variants encoding different isoforms have been isolated for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Werner Helicase Interacting Protein 1
Chromosome: CHR6: 2765665 -2785979
Locus: 6p25.2
Gene Diseases
The WRNIP1 SERPINB6 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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