WRN-LETM2 Fusion FISH Probe
The WRN-LETM2 Fusion FISH Probe is used to confirm a fusion of the WRN and LETM2 genes. The fusion of the WRN and LETM2 genes has been associated with Uterine Carcinosarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WRN-LETM2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-RERE | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-REOR | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-REGO | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-REGR | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-REAQ | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-ORRE | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-OROR | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-ORGO | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-ORAQ | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-GORE | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-GOOR | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-GOGO | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-GOGR | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-GOAQ | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-GRRE | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-GROR | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-GRGO | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-GRGR | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-GRAQ | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-AQRE | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-AQOR | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-AQGO | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-AQGR | 20 (40 μL) | 200 μL |
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| WRN-LETM2-20-AQAQ | 20 (40 μL) | 200 μL |
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WRN Gene Summary
This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017]
Gene Name: Werner Syndrome RecQ Like Helicase
Chromosome: CHR8: 30890777 -31031277
Locus: 8p12
LETM2 Gene Summary
The Leucine Zipper And EF-hand Containing Transmembrane Protein 2 (LETM2) gene is located on chr8 :38243958-38266062 at 8p11.23.
Gene Name: Leucine Zipper And EF-hand Containing Transmembrane Protein 2
Chromosome: CHR8: 38243958 -38266062
Locus: 8p11.23
Gene Diseases
The WRN LETM2 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Carcinosarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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