WRAP53-AHCY Fusion FISH Probe
The WRAP53-AHCY Fusion FISH Probe is used to confirm a fusion of the WRAP53 and AHCY genes. The fusion of the WRAP53 and AHCY genes has been associated with Adrenocortical Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WRAP53-AHCY-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-RERE | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-REOR | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-REGO | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-REGR | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-REAQ | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-ORRE | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-OROR | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-ORGO | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-ORAQ | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-GORE | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-GOOR | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-GOGO | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-GOGR | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-GOAQ | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-GRRE | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-GROR | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-GRGO | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-GRGR | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-GRAQ | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-AQRE | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-AQOR | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-AQGO | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-AQGR | 20 (40 μL) | 200 μL |
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| WRAP53-AHCY-20-AQAQ | 20 (40 μL) | 200 μL |
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AHCY Gene Summary
S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
Gene Name: Adenosylhomocysteinase
Chromosome: CHR20: 32868070 -32899608
Locus: 20q11.22
WRAP53 Gene Summary
This gene encodes an essential component of the telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for telomerase function. It interacts with dyskerin, TERT and TERC, other components of active telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]
Gene Name: WD Repeat Containing Antisense To TP53
Chromosome: CHR17: 7589388 -7606820
Locus: 17p13.1
Gene Diseases
The WRAP53 AHCY Fusion has been associated with the following diseases:
| Disease Name |
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| Adrenocortical Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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