WNT7B-LRP6 Fusion FISH Probe
The WNT7B-LRP6 Fusion FISH Probe is used to confirm a fusion of the WNT7B and LRP6 genes. The fusion of the WNT7B and LRP6 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WNT7B-LRP6-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-RERE | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-REOR | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-REGO | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-REGR | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-REAQ | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-ORRE | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-OROR | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-ORGO | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-ORAQ | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-GORE | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-GOOR | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-GOGO | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-GOGR | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-GOAQ | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-GRRE | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-GROR | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-GRGO | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-GRGR | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-GRAQ | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-AQRE | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-AQOR | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-AQGO | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-AQGR | 20 (40 μL) | 200 μL |
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| WNT7B-LRP6-20-AQAQ | 20 (40 μL) | 200 μL |
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LRP6 Gene Summary
This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
Gene Name: LDL Receptor Related Protein 6
Chromosome: CHR12: 12268960 -12419811
Locus: 12p13.2
WNT7B Gene Summary
This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Among members of the human WNT family, this gene product is most similar to WNT7A protein. [provided by RefSeq, Oct 2008]
Gene Name: Wnt Family Member 7B
Chromosome: CHR22: 46316247 -46373008
Locus: 22q13.31
Gene Diseases
The WNT7B LRP6 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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