WNK3-FGD1 Fusion FISH Probe
The WNK3-FGD1 Fusion FISH Probe is used to confirm a fusion of the WNK3 and FGD1 genes. The fusion of the WNK3 and FGD1 genes has been associated with Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WNK3-FGD1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-RERE | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-REOR | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-REGO | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-REGR | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-REAQ | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-ORRE | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-OROR | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-ORGO | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-ORAQ | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-GORE | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-GOOR | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-GOGO | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-GOGR | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-GOAQ | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-GRRE | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-GROR | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-GRGO | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-GRGR | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-GRAQ | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-AQRE | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-AQOR | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-AQGO | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-AQGR | 20 (40 μL) | 200 μL |
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| WNK3-FGD1-20-AQAQ | 20 (40 μL) | 200 μL |
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FGD1 Gene Summary
This gene encodes a protein that contains Dbl (DH) and pleckstrin (PH) homology domains and is similar to the Rho family of small GTP-binding proteins. The encoded protein specifically binds to the Rho family GTPase Cdc42Hs and can stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. Defects in this gene are the cause of the faciogenital dysplasia in Aarskog-Scott syndrome and a syndromatic form of X-linked cognitive disability. [provided by RefSeq, Jul 2017]
Gene Name: FYVE, RhoGEF And PH Domain Containing 1
Chromosome: CHRX: 54471886 -54522599
Locus: Xp11.22
WNK3 Gene Summary
This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Gene Name: WNK Lysine Deficient Protein Kinase 3
Chromosome: CHRX: 54219255 -54384438
Locus: Xp11.22
Gene Diseases
The WNK3 FGD1 Fusion has been associated with the following diseases:
| Disease Name |
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| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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