WNK2-SECISBP2 Fusion FISH Probe
The WNK2-SECISBP2 Fusion FISH Probe is used to confirm a fusion of the WNK2 and SECISBP2 genes. The fusion of the WNK2 and SECISBP2 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WNK2-SECISBP2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-RERE | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-REOR | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-REGO | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-REGR | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-REAQ | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-ORRE | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-OROR | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-ORGO | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-ORAQ | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-GORE | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-GOOR | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-GOGO | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-GOGR | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-GOAQ | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-GRRE | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-GROR | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-GRGO | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-GRGR | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-GRAQ | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-AQRE | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-AQOR | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-AQGO | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-AQGR | 20 (40 μL) | 200 μL |
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| WNK2-SECISBP2-20-AQAQ | 20 (40 μL) | 200 μL |
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WNK2 Gene Summary
The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Name: WNK Lysine Deficient Protein Kinase 2
Chromosome: CHR9: 95947211 -96082854
Locus: 9q22.31
SECISBP2 Gene Summary
The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2017]
Gene Name: SECIS Binding Protein 2
Chromosome: CHR9: 91933411 -91974561
Locus: 9q22.2
Gene Diseases
The WNK2 SECISBP2 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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