WNK1-RAD52 Fusion FISH Probe
The WNK1-RAD52 Fusion FISH Probe is used to confirm a fusion of the WNK1 and RAD52 genes. The fusion of the WNK1 and RAD52 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WNK1-RAD52-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-RERE | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-REOR | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-REGO | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-REGR | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-REAQ | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-ORRE | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-OROR | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-ORGO | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-ORAQ | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-GORE | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-GOOR | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-GOGO | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-GOGR | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-GOAQ | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-GRRE | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-GROR | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-GRGO | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-GRGR | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-GRAQ | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-AQRE | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-AQOR | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-AQGO | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-AQGR | 20 (40 μL) | 200 μL |
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| WNK1-RAD52-20-AQAQ | 20 (40 μL) | 200 μL |
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RAD52 Gene Summary
The protein encoded by this gene shares similarity with Saccharomyces cerevisiae Rad52, a protein important for DNA double-strand break repair and homologous recombination. This gene product was shown to bind single-stranded DNA ends, and mediate the DNA-DNA interaction necessary for the annealing of complementary DNA strands. It was also found to interact with DNA recombination protein RAD51, which suggested its role in RAD51 related DNA recombination and repair. A pseudogene of this gene is present on chromosome 2. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014]
Gene Name: RAD52 Homolog, DNA Repair Protein
Chromosome: CHR12: 1021254 -1058863
Locus: 12p13.33
WNK1 Gene Summary
This gene encodes a member of the WNK subfamily of serine/threonine protein kinases. The encoded protein may be a key regulator of blood pressure by controlling the transport of sodium and chloride ions. Mutations in this gene have been associated with pseudohypoaldosteronism type II and hereditary sensory neuropathy type II. Alternatively spliced transcript variants encoding different isoforms have been described but the full-length nature of all of them has yet to be determined.[provided by RefSeq, May 2010]
Gene Name: WNK Lysine Deficient Protein Kinase 1
Chromosome: CHR12: 862088 -1020618
Locus: 12p13.33
Gene Diseases
The WNK1 RAD52 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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