WIPF2-MRPL45 Fusion FISH Probe
The WIPF2-MRPL45 Fusion FISH Probe is used to confirm a fusion of the WIPF2 and MRPL45 genes. The fusion of the WIPF2 and MRPL45 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| WIPF2-MRPL45-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-RERE | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-REOR | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-REGO | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-REGR | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-REAQ | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-ORRE | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-OROR | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-ORGO | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-ORAQ | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-GORE | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-GOOR | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-GOGO | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-GOGR | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-GOAQ | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-GRRE | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-GROR | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-GRGO | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-GRGR | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-GRAQ | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-AQRE | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-AQOR | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-AQGO | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-AQGR | 20 (40 μL) | 200 μL |
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| WIPF2-MRPL45-20-AQAQ | 20 (40 μL) | 200 μL |
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MRPL45 Gene Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 2p and 17q. [provided by RefSeq, May 2013]
Gene Name: Mitochondrial Ribosomal Protein L45
Chromosome: CHR17: 36452988 -36479101
Locus: 17q12
WIPF2 Gene Summary
This gene encodes a WASP interacting protein (WIP)-related protein. It has been shown that this protein has a role in the WASP-mediated organization of the actin cytoskeleton and that this protein is a potential link between the activated platelet-derived growth factor receptor and the actin polymerization machinery. [provided by RefSeq, Jul 2008]
Gene Name: WAS/WASL Interacting Protein Family Member 2
Chromosome: CHR17: 38375573 -38438439
Locus: 17q21.2
Gene Diseases
The WIPF2 MRPL45 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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